Sodium Azide → 3-(3-azidopropyl)-5-chloro-1H-indole

HRID 1777525ノート

反応式

HRID 1777525 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[NH:7][CH:6]=1.[N-:15]=[N+:16]=[N-:17].[Na+]>CN(C=O)C>[N:15]([CH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[NH:7][CH:6]=1)=[N+:16]=[N-:17]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 668318443-(3-bromopropyl)-5-chloro-1H-indole

生成物 1

HCID 866993903-(3-azidopropyl)-5-chloro-1H-indole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3-(3-bromopropyl)-5-chloro-1H-indole (0.730 g; 2.68 mmol) and sodium azide (0.522 g; 8.03 mmol) was stirred in DMF (5 mL) for 18 hours and was then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. After separation, the organic layer was dried over magnesium sulfate and the volatiles were evaporated under reduced pressure to give quantitatively 3-(3-azidopropyl)-5-chloro-1H-indole as an oily residue which was used without purification in the next step.

後処理

  1. concentrationwas then concentrated under reduced pressure
  2. customThe residue was partitioned between water and dichloromethane
  3. customAfter separation
  4. dry with materialthe organic layer was dried over magnesium sulfate
  5. customthe volatiles were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-607e49c0ad95427d91256582a9ef2e60
出典データセット
uspto-grants-2016_02
特許番号
US09266832B2

反応ノート

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