Pyridine → Methyl 4-(3-fluorophenoxy)benzoate

HRID 1777578ノート

反応式

HRID 1777578 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1.N1C=CC=CC=1>ClCCl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:12][C:13]1[CH:18]=[C:17]([CH:16]=[CH:15][CH:14]=1)[O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1

参加物

6

反応物 3

HCID 1049PyridineHCID 7456MethylparabenHCID 27339863-Fluorophenylboronic acid

生成物 1

HCID 67973924Methyl 4-(3-fluorophenoxy)benzoate

試薬・触媒・溶媒 2

HCID 8895Cupric acetate触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of methyl 4-hydroxybenzoate (0.400 g; 2.63 mmol), 3-fluorobenzene boronic acid (0.735 g; 5.26 mmol), copper acetate (0.955 g; 5.26 mmol) and pyridine (0.425 mL; 5.26 mmol) in dichloromethane (15 mL) was stirred at room temperature overnight. The reaction mixture was filtered and concentrated under reduced pressure.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-cb1f2ccb3941421198d896d3ed1b911d
出典データセット
uspto-grants-2016_02
特許番号
US09266832B2

反応ノート

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