Sodium Hydroxide → 4-(3-Fluorophenoxy)benzoic acid

HRID 1777579ノート

反応式

HRID 1777579 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1.[OH-].[Na+]>O.O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 67973924Methyl 4-(3-fluorophenoxy)benzoate

生成物 1

HCID 225734424-(3-Fluorophenoxy)benzoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Methyl 4-(3-fluorophenoxy)benzoate (0.202 g; 0.880 mmol) was added to a mixture of NaOH in water (2 mL; 2M) and dioxane (1 mL) and stirred vigorously at room temperature overnight. The resulting mixture was concentrated under reduced pressure and dissolved in water. The aqueous layer was acidified with a solution of hydrogen chloride 6M and the precipitated product was collected by filtration to yield 0.200 g (quantitative) of the title compound as a grey solid which was used without further purification.

後処理

  1. concentrationThe resulting mixture was concentrated under reduced pressure
  2. dissolutiondissolved in water
  3. filtrationthe precipitated product was collected by filtration

出典と根拠

ORDレコード
ord-46122efac23d448b9688b4a0fb87cf1d
出典データセット
uspto-grants-2016_02
特許番号
US09266832B2

反応ノート

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