Diisopropylethylamine → HCID 67973932、化合物

A mixture of 4-((3-fluorophenyl)(methyl)amino)benzoic acid (0.100 g, 0.407 mmol), 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.094 g; 0.407 mmol), HATU (0.170 g; 0.448 mmol) and N,N-diisopropylethylamine (0.176 mL; 1.02 mmol) in DMF (5 mL), was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and sodium hydrogen sulfate, the organic layer was washed with sodium carbonate, brine, dried and concentrated under reduced pressure. The crude mixture was purified by flash chromatography on silica (eluent 2 to 20% ethyl acetate in dichloromethane) to yield 0.048 g (28%) of the title compound as a white solid.

1. customThe reaction mixture was partitioned between ethyl acetate and sodium hydrogen sulfate
2. washthe organic layer was washed with sodium carbonate, brine
3. customdried
4. concentrationconcentrated under reduced pressure
5. customThe crude mixture was purified by flash chromatography on silica (eluent 2 to 20% ethyl acetate in dichloromethane)

ORDレコード

ord-41828336ae25481998f36ae0123609f0

出典データセット

uspto-grants-2016_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09266832B2