Chlorosuccinimide → HCID 89726263、化合物

HRID 1777735ノート

反応式

HRID 1777735 の反応式
[N:1]1([CH2:10][C:11]([OH:13])=[O:12])[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.C1C(=O)N([Cl:21])C(=O)C1>CC#N>[Cl:21][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:1]([CH2:10][C:11]([OH:13])=[O:12])[CH:2]=1

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 22139374(1H-Pyrrolo[2,3-b]pyridin-1-yl)acetic acid

生成物 1

HCID 89726263HCID 89726263、化合物収率 77%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
65 °C

実験手順

To a suspension of 2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid (100 mg) in MeCN (10 mL) was added NCS (91 mg) and the reaction mixture was stirred at 60° C. overnight and at 65° C. for 20 h. The solvent was removed in vacuo, the residue was taken up in DCM and the resulting precipitate was filtered off. The precipitate was further washed with DCM and dried in vacuo. 92 mg of grey solid was obtained. LC-MS (B): tR=0.66 min; [M+H]+: 211.02.

後処理

  1. customThe solvent was removed in vacuo
  2. filtrationthe resulting precipitate was filtered off
  3. washThe precipitate was further washed with DCM
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-239a59c217984798aad5e05da56dbf7a
出典データセット
uspto-grants-2016_02
特許番号
US09266876B2

反応ノート

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