Triphosgene → 6-bromo-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.Cl[C:11](Cl)([O:13]C(=O)OC(Cl)(Cl)Cl)Cl>ClC(Cl)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:11](=[O:13])[NH:9][N:8]=2)[CH:7]=1参加物
4
実験手順
To a solution of 3-2 (2.0 g, 10.6 mmol) in dichloroethane (106 mL) was added triphosgene (3.16 g, 10.64 mmol). The reaction mixture was stirred at room temperature for 3 days. An off-white precipitate formed, which was washed with dichloroethane (100 mL) and dried in vacuo to give 2.03 g (89%) of 3-3 as a tan solid. LC/MS: m/z (M+H)=213.9.
後処理
- customAn off-white precipitate formed
- washwhich was washed with dichloroethane (100 mL)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-7ce35eda23e141ecaaff9d5588663a9d
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266881B2
反応ノート
読み込み中…