2-(Dimethoxymethyl)-1,8-naphthyridine → 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

HRID 1777851ノート

反応式

HRID 1777851 の反応式
[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1>O=[Pt]=O.C(O)C>[CH3:15][O:14][CH:3]([O:2][CH3:1])[C:4]1[N:5]=[C:6]2[C:11]([CH2:10][CH2:9][CH2:8][NH:7]2)=[CH:12][CH:13]=1

参加物

4

反応物 1

HCID 177501752-(Dimethoxymethyl)-1,8-naphthyridine2 回

生成物 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

反応条件

温度
23 °C

実験手順

The procedure described in J. Org. Chem., 2004, 69 (6), pp 1959-1966 was used. Into a 5-l pressure tank reactor (5 atm) was placed 2-(dimethoxymethyl)-1,8-naphthyridine (intermediate 5, 200 g, 979 mmol), ethanol (3 l), PtO2 (12 g). The reactor was evacuated and flushed three times with nitrogen, followed by flushing with hydrogen. The mixture was stirred overnight at 23° C. under an atmosphere of hydrogen. This reaction was repeated four times. The solids were filtered out and the resulting mixture was concentrated under vacuum to give the title compound as a yellow solid.

後処理

  1. customThe reactor was evacuated
  2. customflushed three times with nitrogen
  3. customby flushing with hydrogen
  4. filtrationThe solids were filtered out
  5. concentrationthe resulting mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-4fe2d7741fb74394a96ef141f1e52c86
出典データセット
uspto-grants-2016_02
特許番号
US09266883B2

反応ノート

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