Aldoxime → HCID 178466047、化合物

HRID 17781

反応式

HRID 17781 の反応式
N1C2C=CC=[C:9]([CH:10]=[O:11])C=2N=N1.N[C:13]1[CH:21]=[CH:20][C:16]2[NH:17][N:18]=[N:19][C:15]=2[CH:14]=1.C(=NO)C>C(Cl)Cl>[C:10]([C:13]1[CH:21]=[CH:20][C:16]2[NH:17][N:18]=[N:19][C:15]=2[CH:14]=1)(=[O:11])[CH3:9]

参加物

5

反応物 3

HCID 7863AldoximeHCID 178507366HCID 178507366、化合物HCID 1785194492H-Benzotriazole-4-carbaldehyde

生成物 1

HCID 178466047HCID 178466047、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The ketone was prepared in the same manner as the benzotriazole aldehyde from 5-aminobenzotriazole and acetaldoxime. Column chromatography of the crude ketone using DCM and eluting with MeOH (0-10%) afforded the ketone in 11% yield. Rf [A] 0.3; δH(400 MHz; Acetone-d6) 2.68 (3H, s, CH3), 7.92 (1H, d, J 8.7, Ar—H), 8.07 (1H, d, 3 8.7 Ar—H), 8.62 (1H, s, Ar—H); m/z (FAB−HR) 162.06674 [(M+H)+ calc. for C8H8N3O 162.06682]. The hydrazone of the ketone was prepared from 2,4DNPH to afford an orange solid. 4,6-Dinitro-7-1H-benzotriazole [26]

後処理

  1. washeluting with MeOH (0-10%)

出典と根拠

ORDレコード
ord-b0801a99f04f4e83a219a0e7897fc984
出典データセット
uspto-grants-2010_06
特許番号
US07741102B2

関連ノート

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