Trifluoroacetic acid → 5-Benzyl-4-bromo-1-methyl-1H-pyrazole

反応式

[Br:1][C:2]1[CH:6]=[N:5][N:4]([CH3:7])[C:3]=1[CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)O.C(O)(C(F)(F)F)=O.C([SiH](CC)CC)C>>[CH2:8]([C:3]1[N:4]([CH3:7])[N:5]=[CH:6][C:2]=1[Br:1])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 12052Triethylsilane

HCID 14520172(4-bromo-1-methyl-1H-pyrazol-5-yl)(phenyl)methanol

生成物 1

HCID 867185475-Benzyl-4-bromo-1-methyl-1H-pyrazole

反応条件

温度: 50 °C

実験手順

(4-Bromo-2-methyl-2H-pyrazol-3-yl)-phenyl-methanol (0.50 g; 1.87 mmol) is treated with 3.0 ml TFA and Triethylsilane (1.49 ml; 9.36 mmol) and is heated to 50° C. for 16 hours. The product is purified via reversed phase chromatography under acid conditions.