Trifluoroacetic acid → 1-(2,2,2-Trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate

HRID 1778227ノート

反応式

HRID 1778227 の反応式
[F:1][C:2]([F:19])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6][CH2:5]1.[C:20]([OH:26])([C:22]([F:25])([F:24])[F:23])=[O:21]>ClCCl>[F:23][C:22]([F:25])([F:24])[C:20]([OH:26])=[O:21].[F:19][C:2]([F:1])([F:18])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 22562166tert-Butyl 1-(2,2,2-trifluoroethyl)piperidin-4-ylcarbamate

生成物 1

HCID 1183240701-(2,2,2-Trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Into a 50-mL round-bottom flask, was placed tert-butyl N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]carbamate (2.0 g, 7.08 mmol, 1.00 equip), dichloromethane (20 mL), and CF3COOH (4 mL). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum to yield 1-(2,2,2-trifluoroethyl)piperidin-4-amine 2,2,2-trifluoroacetate as a yellow oil. (ES, m/z) 183 [M+H]+

後処理

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-d2aaff3471bb4580ae8567f251ef6e20
出典データセット
uspto-grants-2016_02
特許番号
US09266835B2

反応ノート

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