Lithium iodide → HCID 66685610、化合物
反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:22]([C:23]([O:25]C)=[O:24])=[C:21]2[C:16]([C:17]3[CH:30]=[CH:29][O:28][C:18]=3[C:19](=[O:27])[NH:20]2)=[CH:15][CH:14]=1)(=[O:11])=[O:10].[I-].[Li+]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:12][C:13]1[C:22]([C:23]([OH:25])=[O:24])=[C:21]2[C:16]([C:17]3[CH:30]=[CH:29][O:28][C:18]=3[C:19](=[O:27])[NH:20]2)=[CH:15][CH:14]=1)(=[O:11])=[O:10]参加物
4
実験手順
A mixture of methyl 7-(2-bromo-4-fluorobenzenesulfonylamino)-4-oxo-4,5-dihydrofuro[2,3-c]quinoline-6-carboxylate (Intermediate 87, 0.220 g) and lithium iodide (0.055 g) in pyridine (13 mL) was irradiated in the microwave at 150° C. for 30 minutes. After cooling, the mixture was concentrated in vacuo and the residue was suspended in 1M HCl. The solid was collected by filtration and triturated with acetone then dried under vacuum to give 7-(2-bromo-4-fluorobenzenesulfonylamino)-4-oxo-4,5-dihydro furo[2,3-c]quinoline-6-carboxylic acid (0.190 g) as a grey solid.