Trifluoroacetic acid → 3-Azetidinol, 3-acetate, 2,2,2-trifluoroacetate (1:1)
反応式
[C:1]([O:4][CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)(=[O:3])[CH3:2].[C:16]([OH:22])([C:18]([F:21])([F:20])[F:19])=[O:17]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[C:16]([OH:22])=[O:17].[NH:7]1[CH2:8][CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH2:6]1参加物
4
実験手順
To a solution of tert-butyl 3-acetoxyazetidine-1-carboxylate (Intermediate 95, 0.914 g) in DCM (5 mL) was added TFA (5 mL) and the mixture was stirred at room temperature for 30 minutes. The resultant mixture was concentrated in vacuo and azeotroped with toluene and diethyl ether to give acetic acid azetidin-3-yl ester trifluoroacetate salt (1.40 g) as a clear oil.
後処理
- concentrationThe resultant mixture was concentrated in vacuo
- customazeotroped with toluene and diethyl ether
出典と根拠
- ORDレコード
- ord-efa45ac8e05a41dbac28ca9a9c221eb9
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09266896B2
反応ノート
読み込み中…