N-Iodosuccinimide → 6-(3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[4,3-b]pyridine

HRID 1778767ノート

反応式

HRID 1778767 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:12]=[C:13]3[NH:19][N:18]=[CH:17][C:14]3=[N:15][CH:16]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[I:20]N1C(=O)CCC1=O>C(Cl)Cl>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([C:11]2[CH:12]=[C:13]3[NH:19][N:18]=[C:17]([I:20])[C:14]3=[N:15][CH:16]=2)[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 867228626-(3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-b]pyridine

生成物 1

HCID 1784934406-(3,5-dimethoxyphenyl)-3-iodo-1H-pyrazolo[4,3-b]pyridine収率 94.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

At r.t. to a solution of 6-(3,5-dimethoxyphenyl)-1H-pyrazolo[4,3-b]pyridine (0.38 g, 1.5 mmol) in methylene chloride (5 mL) was added N-iodosuccinimide (0.352 g, 1.56 mmol) with stirring. The mixture was stirred at r.t. overnight. Then the solvent was removed, the residue was treated with methanol. The solid was collected by filtration to afford the desired product (0.54 g) which was directly used in next step reaction without further purification. LCMS (M+H)+=382.1.

後処理

  1. stirringThe mixture was stirred at r.t. overnight
  2. customThen the solvent was removed
  3. additionthe residue was treated with methanol
  4. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-6f1f007be5fa4717a6fb2430a0f2221c
出典データセット
uspto-grants-2016_02
特許番号
US09266892B2

反応ノート

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