tert-Butyl 4-(4-((4-((5-fluoro-2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate → tert-Butyl 4-(4-((4-(5-fluoro-2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:40][C:41]([O:43][CH3:44])=[O:42])=[C:6]([C:8]#[C:9][C:10]2[C:15]([C:16]([F:19])([F:18])[F:17])=[CH:14][N:13]=[C:12]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([CH:27]4[CH2:32][CH2:31][N:30]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:29][CH2:28]4)=[CH:23][CH:22]=3)[N:11]=2)[CH:7]=1>CCOC(C)=O.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:40][C:41]([O:43][CH3:44])=[O:42])=[C:6]([CH:7]=1)[CH2:8][CH2:9][C:10]1[C:15]([C:16]([F:18])([F:19])[F:17])=[CH:14][N:13]=[C:12]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([CH:27]3[CH2:28][CH2:29][N:30]([C:33]([O:35][C:36]([CH3:38])([CH3:39])[CH3:37])=[O:34])[CH2:31][CH2:32]3)=[CH:25][CH:26]=2)[N:11]=1参加物
4
