Isatin → 3-Methyl-2-phenylquinoline-4-carboxylic acid

HRID 1779361ノート

反応式

HRID 1779361 の反応式
[OH-:1].[Na+].[NH:3]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=O)[C:4]1=[O:5].[C:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=O)[CH2:15][CH3:16]>C(O)C>[C:18]1([C:14]2[C:15]([CH3:16])=[C:6]([C:4]([OH:1])=[O:5])[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:3]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 7054IsatinHCID 71481-Phenyl-1-propanoneHCID 14798Sodium Hydroxide

生成物 1

HCID 6737103-Methyl-2-phenylquinoline-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ten milliliters (2N) of a sodium hydroxide aqueous solution was added dropwise to an ethanol (20 ml) suspension containing 1.47 g of isatin and 2.68 g of propiophenone at room temperature, and the reaction mixture was then heat-refluxed for 26 hours. The resulting reaction mixture was allowed to cool, and then concentrated under reduced pressure. Ice water was added to the residue, and the mixture was extracted with ethyl ether. The aqueous layer was acidified with dilute hydrochloric acid. The precipitate was collected by filtration, and dried to form 1.47 g of the above-mentioned compound.

後処理

  1. temperaturethe reaction mixture was then heat-refluxed for 26 hours
  2. customThe resulting reaction mixture
  3. temperatureto cool
  4. concentrationconcentrated under reduced pressure
  5. additionIce water was added to the residue
  6. extractionthe mixture was extracted with ethyl ether
  7. filtrationThe precipitate was collected by filtration
  8. customdried

出典と根拠

ORDレコード
ord-c48241b95a1440dbad9e22b747187e48
出典データセット
uspto-grants-1997_05
特許番号
US05627193

反応ノート

読み込み中…