Sodium Hydroxide → 86023-87-2

HRID 1779944ノート

反応式

HRID 1779944 の反応式
Br[C@H:2]1[C:28](=[O:29])[C@@:27]2([CH3:30])[C@@H:13]([CH2:14][C@@H:15]3[O:20][C@@:19]4([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]4)[C@@H:17]([CH3:18])[C@@H:16]32)[C@H:12]2[C@H:3]1[C@:4]1([CH3:32])[C@@H:9]([CH2:10][CH2:11]2)[CH2:8][C@@H:7]([OH:31])[CH2:6][CH2:5]1.[OH-:33].[Na+]>O>[CH3:18][C@@H:17]1[C@:19]2([O:26][CH2:25][C@H:23]([CH3:24])[CH2:22][CH2:21]2)[O:20][C@H:15]2[CH2:14][C@@H:13]3[C@@:27]([CH3:30])([C@@H:16]12)[C@H:28]([OH:29])[C:2](=[O:33])[C@H:3]1[C@H:12]3[CH2:11][CH2:10][C@@H:9]2[C@:4]1([CH3:32])[CH2:5][CH2:6][C@H:7]([OH:31])[CH2:8]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10673254HCID 10673254、化合物

生成物 1

HCID 15891086023-87-2

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
83 °C

実験手順

A glass lined reactor was charged with 12.4 Kg of (3β,5α,11β,25R)-11-bromospirostan-3-ol-12-one (24.34 mole), 33 gallons of 33 gallons of water and 7.5 Kg (189 mole, 7.75 eq) of sodium hydroxide pellets. The reaction was heated to reflux over 1.5 hours, maintained at reflux for 4.5 hours (pot temperature was 83° C.), then cooled to room temperature. TLC at this point indicated complete reaction.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux over 1.5 hours
  3. temperaturemaintained
  4. temperaturecooled to room temperature
  5. customreaction

出典と根拠

ORDレコード
ord-988579d585984cc5a212fa7df1bf70d0
出典データセット
uspto-grants-1997_05
特許番号
US05629295

反応ノート

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