Hydrochloric Acid → 3-Phenyloxolan-2-one

HRID 1780212ノート

反応式

HRID 1780212 の反応式
[C:1]1([C:7]([CH2:18][CH2:19][O:20][C:21](=[O:23])C)(C(OCC)=O)C(OCC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:1]1([CH:7]2[CH2:18][CH2:19][O:20][C:21]2=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19050130Diethyl alpha-phenyl-alpha-(2-acetoxyethyl)malonate

生成物 1

HCID 232693-Phenyloxolan-2-one収率 89.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The product of Example 2 (837 g, 2.6M) methanol (1.5 l) and 40% aq. NaOH (1 l, 10M) were heated to reflux for 2 hours. The reaction was then cooled to room temperature and acidified with conc. HCl (1l). The reaction was left as room temperature overnight and then extracted with methyl tert.butyl ether (1 l,500 ml). The extracts were washed with aq. Na2CO3, dried and evaporated to give the title compound(376 g, 89%).

後処理

  1. temperatureto reflux for 2 hours
  2. extractionextracted with methyl tert.butyl ether (1 l,500 ml)
  3. washThe extracts were washed with aq. Na2CO3
  4. customdried
  5. customevaporated

出典と根拠

ORDレコード
ord-7d238d5a0dac4316a959a22dd1e8cc7f
出典データセット
uspto-grants-1997_05
特許番号
US05629432

反応ノート

読み込み中…