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Hydrochloric Acid → 2-Fluoro-6-(4-octyloxyphenyl)pyridine-3-boronic acid

HRID 1780557
ノート
印刷プレビュー

反応式

HRID 1780557 の反応式
C(NC(C)C)(C)C.C([Li])CCC.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:22][CH:21]=2)[N:15]=1.[B:35](OC(C)C)([O:40]C(C)C)[O:36]C(C)C.Cl.[Cl-].[Na+]>O1CCCC1.CCCCCC>[F:13][C:14]1[C:19]([B:35]([OH:40])[OH:36])=[CH:18][CH:17]=[C:16]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:22][CH:21]=2)[N:15]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

9

反応物 6

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 7912DiisopropylamineHCID 21531Triisopropyl borateHCID 179115002-(4-Octyloxyphenyl)-6-fluoropyridineHCID 178418339Butyllithium

生成物 1

HCID 19046950
2-Fluoro-6-(4-octyloxyphenyl)pyridine-3-boronic acid
収率 78.5%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8058Hexane溶媒

反応条件

温度
-78 °C

実験手順

8.00 ml (56.80 mmol) of diisopropylamine in 10 ml of tetrahydrofuran are stirred at 0° C. with 35.70 ml (56.80 mmol) of a 1.6-molar n-butyllithium solution in hexane for 1 hour. After cooling to -78° C., 8.56 g (28.40 mmol) of 2-fluoro-6-(4-octyloxyphenyl)pyridine (prepared as described in Example 2) in 1000 ml of tetrahydrofuran are added dropwise, and the mixture is stirred at -78° C. for 4 hours. 21.25 g (113.00 mmol) of triisopropyl borate are then added dropwise at -78° C., and the reaction mixture is stirred overnight, during which it warms to room temperature. After addition of 100 ml of 10% hydrochloric acid and stirring at room temperature for one hour, sodium chloride solution is added, the mixture is extracted with ether, the ether phase is washed with sodium chloride solution, dried over sodium sulfate, filtered and concentrated. Recrystallization from acetonitrile gives 7.70 g of 2-fluoro-6-(4-octyloxyphenyl)pyridine-3-boronic acid. ##STR29##

後処理

  1. stirringthe reaction mixture is stirred overnight, during which it
  2. customwarms to room temperature
  3. stirringstirring at room temperature for one hour
  4. extractionthe mixture is extracted with ether
  5. washthe ether phase is washed with sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customRecrystallization from acetonitrile

出典と根拠

ORDレコード
ord-4962c978bc824e2e99e63ceab2130d15
出典データセット
uspto-grants-1997_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05630962

反応ノート

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