Iodoethanol → 1-(2-Hydroxyethyl)-1-methyl-4-(benzoxazol-2-yl)homo-piperazinium iodide

HRID 1780669ノート

反応式

HRID 1780669 の反応式
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1.[I:18][CH2:19][CH2:20][OH:21]>C1COCC1>[I-:18].[OH:21][CH2:20][CH2:19][N+:2]1([CH3:1])[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 12225IodoethanolHCID 105856212-(4-Methyl-1-homopiperazinyl)benzoxazole

生成物 1

HCID 190472761-(2-Hydroxyethyl)-1-methyl-4-(benzoxazol-2-yl)homo-piperazinium iodide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A 100 mg portion of 2-(4-methyl-1-homopiperazinyl)-benzoxazole was dissolved in 3 ml of THF. Under cooling with ice, 89 mg of 2-iodoethyl alcohol was added to the thus prepared solution, and the reaction was carried out for 1 hour at the same temperature and then for 29 hours at room temperature. The reaction solution was concentrated under a reduced pressure, and 3 ml of acetone was added to the resulting residue. The precipitate thus formed was collected by filtration, washed with acetone and then dried to obtain 143 mg of the title compound.

後処理

  1. additionwas added to the thus prepared solution
  2. waitfor 29 hours at room temperature
  3. concentrationThe reaction solution was concentrated under a reduced pressure, and 3 ml of acetone
  4. additionwas added to the resulting residue
  5. customThe precipitate thus formed
  6. filtrationwas collected by filtration
  7. washwashed with acetone
  8. customdried

出典と根拠

ORDレコード
ord-3c1c44bac39e4726bd010ab1cffe6729
出典データセット
uspto-grants-1997_05
特許番号
US05631257

反応ノート

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