2,5 Dibromotoluene → 1,4-Dibromo-2-(bromomethyl)benzene

HRID 1780900ノート

反応式

HRID 1780900 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1>C(Cl)(Cl)(Cl)Cl.C(OOCC1C=CC=CC=1)C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][Br:17]

参加物

5

反応物 2

HCID 120062,5 DibromotolueneHCID 67184N-bromobutanimide

生成物 1

HCID 53260381,4-Dibromo-2-(bromomethyl)benzene収率 55.7%

試薬・触媒・溶媒 2

HCID 11229634Benzyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 75 g (0.3 mol) of 2,5-dibromotoluene in 1 L of carbon tetrachloride was added 58.73 g (0.33 mol) of NBS and 50 mg of benzyl peroxide, and the resulting mixture was refluxed with stirring for 24 h. The mixture was cooled, and concentrated in vacuo. The residue was crystallized from hot methanol and washed with hexane to afford 54.5 g (55.7%) of 2,5-dibromobenzyl bromide as a solid.

後処理

  1. temperaturethe resulting mixture was refluxed
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated in vacuo
  4. customThe residue was crystallized from hot methanol
  5. washwashed with hexane

出典と根拠

ORDレコード
ord-97e68516a7b54210978c6375755505c7
出典データセット
uspto-grants-1997_05
特許番号
US05631264

反応ノート

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