Sodium Carbonate → N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide

反応式

Cl[CH2:2][C:3]([N:5]([CH:13]([CH3:15])[CH3:14])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:4].C(=O)([O-])[O-:17].[Na+].[Na+]>>[OH:17][CH2:2][C:3]([N:5]([CH:13]([CH3:15])[CH3:14])[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:4]

参加物

反応物 2

HCID 10340Sodium Carbonate

HCID 109662942-Chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide

生成物 1

HCID 6452934N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide

反応条件

温度: 100 °C

実験手順

In a 500 ml flask, 23.0 g (0.1 mol) of N-chloroacetyl-N-isopropyl-4-fluoroaniline and 11.7 g (0.11 mol) of sodium carbonate in 340 ml of solvent or solvent mixture are heated with stirring to reflux temperature (100° C.). The reaction is monitored by gas chromatography (sampling after in each case 1 hour). The results are compiled in the table which follows.

後処理

aliquotsampling after in each case 1 hour)

出典と根拠

ORDレコード: ord-57751326651f4ba2b298994bf5add7b7
出典データセット: uspto-grants-1997_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05631403

反応ノート

読み込み中…