Methylamine → N-Methyl-1-(4-phenoxyphenyl)methanamine
反応式
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][NH2:17].C(OCC)(=O)C>CO.[Pd]>[CH3:16][NH:17][CH2:12][C:11]1[CH:14]=[CH:15][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][CH:10]=1参加物
6
実験手順
4-Phenoxybenzaldehyde (10.0 g, 0.05 mol), excess methylamine and 1.5 g of 10% Pd/C in 200 mL of methanol were stirred under an atmosphere of hydrogen for 16 hours. After removal of the catalyst by filtration through Celite®, the filtrate was concentrated under reduced pressure to give the crude product as an oil. Chromatography on silica gel eluting with ethyl acetate gave the title compound in 80% yield.
後処理
- customAfter removal of the catalyst
- filtrationby filtration through Celite®
- concentrationthe filtrate was concentrated under reduced pressure
- customto give the crude product as an oil
出典と根拠
- ORDレコード
- ord-9172f8c663b2415390d899a38b676f70
- 出典データセット
- uspto-grants-1997_05
- 特許番号
- US05631401
反応ノート
読み込み中…