Sodium Hydroxide → 6-Cyano-4,4-diphenylhexanoic acid

HRID 1781503ノート

反応式

HRID 1781503 の反応式
[C:1]([CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:6][CH2:7][C:8]([O:10]CC)=[O:9])#[N:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:6][CH2:7][C:8]([OH:10])=[O:9])#[N:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19610260Ethyl 6-cyano-4,4-diphenylhexanoate

生成物 1

HCID 190455936-Cyano-4,4-diphenylhexanoic acid収率 94.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

To a solution of ethyl 6-cyano-4,4-diphenylhexanoate (25.5 g) in ethanol (400 ml) was added 1N-aqueous sodium hydroxide solution (120 ml) and the mixture was heated and stirred at 60° C. for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the group was made acidic to with 1N-hydrochloric acid and extracted with ethyl acetate (200 ml×2). The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated to dryness. The group (25 g) was recrystallized from chloroform-hexane to provide the title compound (22 g) as white powder.

後処理

  1. temperaturethe mixture was heated
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. extractionextracted with ethyl acetate (200 ml×2)
  5. washThe extract was washed with saturated aqueous sodium chloride solution
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated to dryness
  8. customThe group (25 g) was recrystallized from chloroform-hexane

出典と根拠

ORDレコード
ord-c45ce467eda245a8a90c7c579be52209
出典データセット
uspto-grants-1997_05
特許番号
US05633248

反応ノート

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