Sodium Hydroxide → HCID 9865634、化合物

HRID 1781514ノート

反応式

HRID 1781514 の反応式
C([NH:3][CH2:4][C:5]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=O.[OH-].[Na+]>CO>[NH2:3][CH2:4][C:5]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 9888730HCID 9888730、化合物

生成物 1

HCID 9865634HCID 9865634、化合物収率 100.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1-(5-formylamino-4,4-diphenylpentyl)-4-phenylpiperidine (2.07 g) in methanol (50 ml) was added 1N-sodium hydroxide (30 ml) and the mixture was refluxed overnight. This reaction mixture was concentrated to dryness and the group was extracted using methylene chloride and water. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to dryness to provide the title compound (1.94 g) as yellow powder.

後処理

  1. temperaturethe mixture was refluxed overnight
  2. concentrationThis reaction mixture was concentrated to dryness
  3. extractionthe group was extracted
  4. washThe organic layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-8f22d5e763004e2ebbd516fb90970a8d
出典データセット
uspto-grants-1997_05
特許番号
US05633248

反応ノート

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