Sodium Hydroxide → HCID 178518972、化合物

HRID 1781617ノート

反応式

HRID 1781617 の反応式
[OH-:1].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[C:14](Cl)=[N:13][N:12]=[N:11]1>O>[CH:7]1[CH:6]=[C:5]([N:10]2[NH:11][N:12]=[N:13][C:14]2=[O:1])[C:4]([Cl:3])=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 153465581-(2-Chloro-phenyl)-5-chlorotetrazole

生成物 1

HCID 178518972HCID 178518972、化合物収率 96%

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

反応条件

温度
110 °C

実験手順

A solution of sodium hydroxide (13 g, about 45% by weight) in water, 1-(2-chloro-phenyl)-5-chlorotetrazole (12.9 g) in water (6.5 ml) were mixed and the mixture was heated to 110° C. The reaction was initiated and the temperature increased to 115° C. After 3 minutes from the initiation of the reaction, the temperature was lowered to room temperature and then water (20 ml) was added. The insoluble matter was extracted with toluene (10 ml) and the aqueous solution was adjusted to a pH of 1. The solid matter was collected by filtration followed by washing with water and drying to obtain a pale tan solid 1-(2-chlorophenyl)-5(4H)-tetrazolinone (11.3 g) (yield: 96%). melting point: 123°-125° C.

後処理

  1. temperaturethe temperature increased to 115° C
  2. customAfter 3 minutes from the initiation of the reaction
  3. customwas lowered to room temperature
  4. extractionThe insoluble matter was extracted with toluene (10 ml)
  5. filtrationThe solid matter was collected by filtration
  6. washby washing with water
  7. customdrying

出典と根拠

ORDレコード
ord-a71703d6b6b4447d8aef3942b26b3745
出典データセット
uspto-grants-1997_05
特許番号
US05633387

反応ノート

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