Hydrochloric Acid → 2-Amino-4-chloro-6-nitrobenzoic acid

HRID 1781635ノート

反応式

HRID 1781635 の反応式
[OH:1]O.[Cl:3][C:4]1[CH:12]=[C:11]2[C:7]([C:8](=[O:14])C(=O)[NH:10]2)=[C:6]([N+:15]([O-:17])=[O:16])[CH:5]=1.Cl>[OH-].[Na+]>[Cl:3][C:4]1[CH:12]=[C:11]([NH2:10])[C:7](=[C:6]([N+:15]([O-:17])=[O:16])[CH:5]=1)[C:8]([OH:14])=[O:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 19046765HCID 19046765、化合物

生成物 1

HCID 190467352-Amino-4-chloro-6-nitrobenzoic acid収率 87.8%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

4 ml of a 30% hydrogen peroxide solution are added dropwise at room temperature to 3.8 g (16.7 mmol) of 6-chloro-4-nitro-indoline-2,3-dione in 60 ml of sodium hydroxide solution. The mixture is stirred for 2 hours at room temperature, acidified to pH 2 to 3 with 4N hydro-chloric acid, filtered and dried. 3.18 g (87.8% of theory) of 4-chloro-6-nitro-anthranilic acid having a melting point of 202°-205° are obtained.

後処理

  1. filtrationfiltered
  2. customdried

出典と根拠

ORDレコード
ord-03f44ecdfc44402a90066612773e8a0e
出典データセット
uspto-grants-1997_05
特許番号
US05633379

反応ノート

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