1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichlorophenyl)3-(thieno[3,2-d]pyrimidin-4-yl)urea

HRID 1782069

反応式

HRID 1782069 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=[O:11].[NH2:12][C:13]1[C:14]2[S:21][CH:20]=[CH:19][C:15]=2[N:16]=[CH:17][N:18]=1>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][C:13]1[C:14]2[S:21][CH:20]=[CH:19][C:15]=2[N:16]=[CH:17][N:18]=1)=[O:11]

参加物

4

反応物 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 11506485Thieno(3,2-d)pyrimidin-4-amine

生成物 1

HCID 99239551-(2,6-Dichlorophenyl)3-(thieno[3,2-d]pyrimidin-4-yl)urea収率 229.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2,6-Dichlorophenyl isocyanate (0.075 g) was added to a mixture of 4-aminothieno[3,2-d]pyrimidine (Tetrahedron, 1971, 27, 487; 0.201 g) and acetonitrile (16 ml) and the resultant mixture was stirred at ambient temperature for 16 hours. The precipitate was isolated and washed in turn with diethyl ether and methanol. There was thus obtained the title compound (0.31 g); NMR Spectrum: (DMSOd6) 7.25 (t, 1H), 7.45 (d, 1H), 7.55 (d, 1H), 7.95 (d, 1H), 8.4 (s, 1H), 8.8 (s, 1H), 11.7 (br s, 1H); Mass Spectrum: M+H+ 339 and 341; Elemental Analysis: Found C, 45.8; H 2.4; N, 16.5; C13H8Cl2N4OS requires C, 46.03; H, 2.38; N, 16.52%.

後処理

  1. customThe precipitate was isolated
  2. washwashed in turn with diethyl ether and methanol

出典と根拠

ORDレコード
ord-8db3ef97975143c1821bcb5b829ec461
出典データセット
uspto-grants-2009_03
特許番号
US07498335B2

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