HCID 22649188、化合物 → HCID 22649208、化合物

HRID 1782079ノート

反応式

HRID 1782079 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[NH:15][C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N+:25]([O-])=O)=[O:17]>[Pd].CN(C=O)C>[NH2:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[NH:18][C:16]([NH:15][C:6]1[C:5]2[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[N:9]=[CH:8][N:7]=1)=[O:17]

参加物

4

反応物 1

HCID 22649188HCID 22649188、化合物

生成物 1

HCID 22649208HCID 22649208、化合物収率 82.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 1-(6,7dimethoxyquinazolin-4-yl)-3-(2-nitrophenyl)urea (0.18 g), 10% palladium charcoal catalyst (0.023 g) and DMF (10 ml) was stirred at ambient temperature under an atmosphere of hydrogen for 16 hours. The reaction mixture was filtered and the filtrate was evaporated. The resultant gum was triturated under ethyl acetate and there was thus obtained the title compound as a solid (0.137 g); NMR Spectrum: (DMSOd6) 3.95-3.95 (br s, 8H), 6.63 (t, 1H), 6.81 (d, 1H), 6.91 (t, 1H), 7.25 (s, 1H), 7.47 (d, 1H), 8.05 (s, 1H), 8.64 (s, 1H), 10.28 (br, s, 1H), 11.74 (br, s, 1H); Mass spectrum M+H+340.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe resultant gum was triturated under ethyl acetate

出典と根拠

ORDレコード
ord-e167641bb4ba41f38ad99a7e66918a01
出典データセット
uspto-grants-2009_03
特許番号
US07498335B2

反応ノート

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