Ammonium Chloride → 5-Bromo-2-(2H-tetrazol-5-yl)pyridine
反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]#[N:9])=[CH:6][CH:7]=1.[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+]>CN(C)C=O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[N:10][N:9]=2)=[N:4][CH:3]=1参加物
6
反応条件
- 温度
- 120 °C
実験手順
A mixture of 3-bromo-6-cyano-pyridine (2 g, 10.9 mmol), sodium azide (0.85 g, 13 mmol), and ammonium chloride (0.59 g, 11 mmol) in N,N-dimethylformamide (20 mL) was heated for 1 h at 120° C. The reaction mixture was diluted with ethyl acetate (˜100 mL) and the product was isolated by filtration and then washed with ethyl acetate to give the title compound, an off-white amorphous solid which was used in the next step without further purification.
後処理
- customthe product was isolated by filtration
- washwashed with ethyl acetate
出典と根拠
- ORDレコード
- ord-f08ba27cbfad482bb60f59a43d1dedba
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07498350B2
反応ノート
読み込み中…