N-(2-Acetylphenyl)acetamide → N-[2-(2-bromoacetyl)phenyl]acetamide

HRID 1782709

反応式

HRID 1782709 の反応式
[Br:1]Br.[C:3]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:15])[CH3:14])(=[O:5])[CH3:4]>C(Cl)(Cl)Cl>[C:3]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:15])[CH2:14][Br:1])(=[O:5])[CH3:4]

参加物

4

反応物 2

HCID 21306N-(2-Acetylphenyl)acetamideHCID 24408Bromine

生成物 1

HCID 2749459N-[2-(2-bromoacetyl)phenyl]acetamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

45.0 g (0.282 mol) of dry bromine were added dropwise to a boiling solution of 50.0 g (0.282 mol) of 1-[2-(acetylamino)phenyl]ethanone in 400 ml of chloroform at room temperature. The solvent was distilled off, the residue was distributed between dichloromethane and saturated ice-cold sodium hydrogen carbonate solution. The organic phase was dried over sodium sulphate, evaporated down in vacuo, the residue was triturated with diethylether and suction filtered. After drying in vacuo 35.4 g (49% of theory) of colourless crystals were obtained, Rf=0.48 (eluant: petroleum ether/ethyl acetate 2/1 v/v).

後処理

  1. distillationThe solvent was distilled off
  2. dry with materialThe organic phase was dried over sodium sulphate
  3. customevaporated down in vacuo
  4. customthe residue was triturated with diethylether and suction
  5. filtrationfiltered
  6. customAfter drying in vacuo 35.4 g (49% of theory) of colourless crystals
  7. customwere obtained

出典と根拠

ORDレコード
ord-926f7b0a23cc4338b77caa0fd2afa495
出典データセット
uspto-grants-2009_03
特許番号
US07498325B2

関連ノート

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