Water → [(4-Bromobutoxy)methyl]cyclopropane

HRID 1782759ノート

反応式

HRID 1782759 の反応式
[H-].[Na+].[OH:3][CH2:4][CH:5]1[CH2:7][CH2:6]1.[Br:8][CH2:9][CH2:10][CH2:11][CH2:12]Br.O>C1(C)C=CC=CC=1>[Br:8][CH2:9][CH2:10][CH2:11][CH2:12][O:3][CH2:4][CH:5]1[CH2:7][CH2:6]1

参加物

6

反応物 4

HCID 962WaterHCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 75644Cyclopropanemethanol

生成物 1

HCID 43165202[(4-Bromobutoxy)methyl]cyclopropane

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
100 °C

実験手順

2.8 g of a 60% suspension of sodium hydride in mineral oil are added in portions to a solution of 5.0 g of hydroxymethylcyclopropane in 25 ml of toluene at room temperature. The mixture is then heated at 100° C. for 2 hours. After this, it is allowed to reach room temperature and a solution of 14.9 g of 1,4-dibromobutane in 15 ml of toluene is added. The mixture is left to stir at 100° C. for a further 15 hours. Then, at room temperature, 10 ml of water are added, the phases are separated, and the toluene is removed in a rotary evaporator. The product is isolated by vacuum distillation.

後処理

  1. customto reach room temperature
  2. waitThe mixture is left
  3. customthe phases are separated
  4. customthe toluene is removed in a rotary evaporator
  5. customThe product is isolated by vacuum distillation

出典と根拠

ORDレコード
ord-de5d8c77679b477e87e86417d7ec09d3
出典データセット
uspto-grants-2009_03
特許番号
US07498460B2

反応ノート

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