Sodium Hydroxide → 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid

HRID 1783554ノート

反応式

HRID 1783554 の反応式
[CH:1]([NH:4][C:5]1[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([NH:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 10491237Ethyl 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylate

生成物 1

HCID 127840854-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid収率 90%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of 5.0 g (19.6 mmol) of ethyl 4-(isopropylamino)-2-(methylthio)pyrimidine-5-carboxylate in 20 mL of ethanol is added a solution of 0.8 g (20.6 mmol) of sodium hydroxide in 30 mL of water. The reaction suspension is stirred at room temperature overnight. The reaction solution is diluted with 100 mL of water and washed twice with diethyl ether. The aqueous phase is neutralized with 20.6 mL of 1N HCl. The precipitate is filtered and washed twice with water, dried under vacuum at 70° C. to give 4.0 g (90%) of the title compound: mp 202-203° C. (dec).

後処理

  1. washwashed twice with diethyl ether
  2. filtrationThe precipitate is filtered
  3. washwashed twice with water
  4. customdried under vacuum at 70° C.

出典と根拠

ORDレコード
ord-fe62e3f1d3e445e1a47193d0675cf0e7
出典データセット
uspto-grants-2009_03
特許番号
US07501425B1

反応ノート

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