Thionyl Chloride → 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid chloride
反応式
[CH:1]([NH:4][C:5]1[C:10]([C:11](O)=[O:12])=[CH:9][N:8]=[C:7]([S:14][CH3:15])[N:6]=1)([CH3:3])[CH3:2].S(Cl)([Cl:18])=O>>[CH:1]([NH:4][C:5]1[C:10]([C:11]([Cl:18])=[O:12])=[CH:9][N:8]=[C:7]([S:14][CH3:15])[N:6]=1)([CH3:3])[CH3:2]参加物
3
反応条件
- 温度
- 50 °C
実験手順
To 3.5 (15.4 mmol) of 4-(isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid is added 9.0 mL (123.2 mmol) of thionyl chloride, and the reaction mixture is heated at 50° C. for 1 hour, cooled to room temperature, and concentrated. The residue is twice suspended in anhydrous toluene and concentrated to give a colorless solid, 4-(isopropylamino)-2-(methylthio) pyrimidine-5-carboxylic acid chloride.
後処理
- temperaturecooled to room temperature
- concentrationconcentrated
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-3b250297335942b299c47a4902d0c23c
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07501425B1
反応ノート
読み込み中…