HCID 68484162、化合物 → HCID 59733160、化合物
反応式
C(OC(=O)[NH:10][C@@H:11]([CH3:25])[CH2:12][NH:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1)C1C=CC=CC=1>C(O)C.[Pd]>[F:22][C:21]([F:23])([F:24])[O:20][C:17]1[CH:16]=[CH:15][C:14]([NH:13][CH2:12][C@@H:11]([NH2:10])[CH3:25])=[CH:19][CH:18]=1参加物
4
実験手順
[1-(S)-Methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-carbamic acid benzyl ester (23.9 mmol) was dissolved in ethanol (200 mL) then placed under nitrogen. 10% Palladium on carbon was added (0.5 g) and the mixture was stirred under hydrogen (atmospheric pressure) overnight. When reaction was complete, the mixture was filtered through celite. The celite was washed with ethanol (5×50 ml) then evaporated in vacuo to give a brown oil (4.03 g, 17.21 mmol, 72% yield over 3 steps).