Ethylorthoformate → 4-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

HRID 17839

反応式

HRID 17839 の反応式
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=2[S:14]([NH2:17])(=[O:16])=[O:15])[CH2:3][CH2:2]1.[CH:18]([O-])([O-])OCC>>[CH:1]1([N:4]2[C:5]3[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=3[S:14](=[O:16])(=[O:15])[N:17]=[CH:18]2)[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 53630039EthylorthoformateHCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

生成物 1

HCID 675307714-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

反応条件

温度
130 °C

実験手順

In a round-bottom flask, a mixture of 2-cyclopropylamino-5-nitrobenzenesulphonamide (5 g), originating from the Step above, and ethyl orthoformate (50 mL) is heated in the open state at 130° C. for 3 hours. The suspension obtained is cooled on an ice bath and the insoluble material is collected by filtration, washed with ether and dried.

後処理

  1. customThe suspension obtained
  2. temperatureis cooled on an ice bath
  3. filtrationthe insoluble material is collected by filtration
  4. washwashed with ether
  5. customdried

出典と根拠

ORDレコード
ord-d3c399511b97447abf51faf290d79fe9
出典データセット
uspto-grants-2010_06
特許番号
US07741320B2

関連ノート

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