1,3-Benzodioxol-4-amine → 3-Cyano-7-hydroxy-6-methoxy-4-(2,3-methylenedioxyanilino)quinoline
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:15]#[N:16].[CH2:17]1[O:26][C:25]2[C:19](=[C:20]([CH:22]=[CH:23][CH:24]=2)[NH2:21])[O:18]1>C(O)CC>[C:15]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:21][C:20]1[CH:22]=[CH:23][CH:24]=[C:25]3[O:26][CH2:17][O:18][C:19]=13)=[CH:10][C:9]([O:12][CH3:13])=[C:8]([OH:14])[CH:7]=2)#[N:16]参加物
4
反応条件
- 温度
- 115 °C
実験手順
A mixture of 4-chloro-3-cyano-7-hydroxy-6-methoxyquinoline (5 g), 2,3-methylenedioxyaniline (3.07 g) and propanol (100 ml) was stirred and heated to 115° C. for 18 hours. The resultant precipitate was isolated, washed in turn with propanol and diethyl ether and dried under vacuum. There was thus obtained the title compound (5.51 g); NMR Spectrum: (DMSOd6) 3.99 (s, 3H), 6.06 (s, 2H), 6.93-7.0 (m, 3H), 7.48 (s, 1H), 8.16 (s, 1H), 8.94 (s, 1H); Mass Spectrum: M+H+ 336.