3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester → 3-(4-Aminomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
反応式
[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]=[N+]=[N-])=[CH:8][C:7]=1[CH3:16].[H][H]>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[CH3:16]参加物
5
実験手順
A mixture of 3-(4-Azidomethyl-2-methyl-phenyl)-propionic acid methyl ester (0.20 g, 0.86 mmol) and 5% Pd/C (32 mg) in EtOH (50 mL) is exposed to a hydrogen atmosphere (60 psi) at RT overnight. Upon filtering the mixture through Celite, the filtrate is concentrated to yield the title compound (0.14 g, 78%). The material is used without further purification.
後処理
- filtrationUpon filtering the mixture through Celite
- concentrationthe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-94a6019a1fd24619b8cf383a7ae1c3be
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504433B2
反応ノート
読み込み中…