Hydrochloric Acid → (2R)-2-hydroxy-2-(2-methoxyphenyl)acetic acid
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@H:9]([OH:14])[C:10]([O:12]C)=[O:11].[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@H:9]([OH:14])[C:10]([OH:12])=[O:11]参加物
5
実験手順
To a solution of 19 g of methyl (2R)-2-(methoxyphenyl)-2-hydroxyethanoate (cf. Journal of Chemical Society, Parkintrans 1, 2253-2255 (1992)) in 50 ml of methanol, 50 ml of 3N aqueous sodium hydroxide solution was added, followed by 12 hours' stirring at room temperature. Distilling the methanol off under reduced pressure, the reaction liquid was acidified with 1N hydrochloric acid and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure, to provide 11 g of the title compound.
後処理
- distillationDistilling the methanol off under reduced pressure
- customthe reaction liquid
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- distillationthe solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-debd0f3dfe2643b0a287161a47507876
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504432B2
反応ノート
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