2,4'-Dichlorobenzophenone → (2-Chlorophenyl)(4-chlorophenyl)methanol

HRID 1785632

反応式

HRID 1785632 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH:4]([OH:5])[C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 665582,4'-DichlorobenzophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 247332(2-Chlorophenyl)(4-chlorophenyl)methanol収率 78%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred solution of 2,4′-dichlorobenzophenone (239 mmol) in methanol (400 mL) was added sodium borohydride (119 mmol) portionwise at 0° C. Reaction mixture was warmed to room temperature and stirred for 1 hour, then quenched with water and the methanol was removed under reduced pressure. The residue was diluted with dichloromethane (400 mL) and washed with water and brine, dried (MgSO4) and concentrated in vacuo to yield the product as an orange oil (47.1 g, 78%).

後処理

  1. customReaction mixture
  2. customquenched with water
  3. customthe methanol was removed under reduced pressure
  4. additionThe residue was diluted with dichloromethane (400 mL)
  5. washwashed with water and brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0a11525eb48d4e06a5e6cf67c09aa1bb
出典データセット
uspto-grants-2009_03
特許番号
US07504522B2

関連ノート

読み込み中…