Acetyl chloride → 2-(Piperidin-1-yl)acetamide
反応式
[N:1]1(N)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:8]([N:11](C(C)C)CC)(C)[CH3:9].C(Cl)(=[O:19])C.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[N:1]1([CH2:9][C:8]([NH2:11])=[O:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
6
実験手順
To a solution of the piperidine amine obtained above (676 mg, 1.59 mmol) in methylene chloride (25 mL) was added diisopropylethylamine (616 mg, 849 uL, 4.77 mmol), followed by acetyl chloride (162 mg, 156 uL, 2.06 mmol). The mixture was stirred at room temperature over night. The reaction mixture was poured into saturated aqueous sodium bicarbonate and extracted with additional methylene chloride. The extracts were combined, washed with brine, dried over sodium sulfate, filtered, dried and concentrated to afford the piperidine acetamide (844 mg, >100%).
後処理
- extractionextracted with additional methylene chloride
- washwashed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-827d3689fd1b434982c9c48ed847e029
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07504508B2
反応ノート
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