Hydrazine hydrate (1:1) → HCID 67549266、化合物
反応式
C([O:3][C:4](=O)[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH2:8][C:7]1=[O:12])C.O.[NH2:15][NH2:16]>C(O)CCC>[O:12]=[C:7]1[CH2:8][O:9][CH2:10][CH2:11][N:6]1[CH2:5][C:4]([NH:15][NH2:16])=[O:3]参加物
4
実験手順
As described for example 112a, (3-oxo-morpholin-4-yl)-acetic acid ethyl ester in butanol was reacted with hydrazine hydrate at 100° C. for 6 h. Evaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1) afforded the title compound as a white solid (yield: 56%). MS: m/e=174.4 [M+H]+.
後処理
- customEvaporation of all volatiles and chromatography (SiO2, dichloromethane:methanol:aq.ammonia (25%)=100:0:0 to 90:10:1)
出典と根拠
- ORDレコード
- ord-f35efdd69a31478bb964ca8976c7d05e
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07507729B2
反応ノート
読み込み中…