Hydrazine hydrate (1:1) → 2-(5-Methylisoxazol-3-yl)acetohydrazide
反応式
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:9]=[C:8]([CH3:10])[O:7][N:6]=1.O.[NH2:13][NH2:14]>C(O)CCC>[CH3:10][C:8]1[O:7][N:6]=[C:5]([CH2:4][C:3]([NH:13][NH2:14])=[O:2])[CH:9]=1参加物
4
実験手順
As described for example 112a, (5-methyl-isoxazol-3-yl)-acetic acid methyl ester in butanol was reacted with hydrazine hydrate (2 equivalents) and the resulting mixture was heated under reflux for 90 min. Evaporation of all volatiles afforded the title compound as a white solid (yield: 90%). 1H-NMR (300 MHz, DMSO): δ=2.36 (d, J=0.7 Hz, 3H), 3.39 (s, 2H), 4.25 (s, 2H), 6.13 (d, J=0.7 Hz, 1H), 9.27 (s, 1H).
後処理
- temperaturethe resulting mixture was heated
- temperatureunder reflux for 90 min
- customEvaporation of all volatiles
出典と根拠
- ORDレコード
- ord-92db03ef5bef403a9021ddf50163f35d
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07507729B2
反応ノート
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