Hydrazine hydrate (1:1) → HCID 63579409、化合物

HRID 1786229ノート

反応式

HRID 1786229 の反応式
C([O:3][C:4](=O)[CH2:5][N:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]1=[O:13])C.O.[NH2:16][NH2:17]>C(O)C>[CH3:12][C:11]1[N:6]([CH2:5][C:4]([NH:16][NH2:17])=[O:3])[C:7](=[O:13])[CH:8]=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 14196015Ethyl 6-methyl-2-oxo-1(2H)-pyridineacetate

生成物 1

HCID 63579409HCID 63579409、化合物収率 88%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

As described for example 112a, (6-methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester (Petride, Horia; Raileanu, Dan. Revue Roumaine de Chimie (1988), 33(7), 729-39.) in ethanol was reacted with hydrazine hydrate (1.8 equivalents) at rt for 96 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 88%). MS: m/e=204.2 [M+Na]+.

後処理

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

出典と根拠

ORDレコード
ord-f658d5b309bd4d8f99d01cf06c94cfd0
出典データセット
uspto-grants-2009_03
特許番号
US07507729B2

反応ノート

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