Hydrazine hydrate (1:1) → 2-(3-Methyl-2-oxopyridin-1(2H)-yl)acetohydrazide

HRID 1786231ノート

反応式

HRID 1786231 の反応式
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:7]1=[O:13])C.O.[NH2:16][NH2:17]>C(O)C>[CH3:12][C:8]1[C:7](=[O:13])[N:6]([CH2:5][C:4]([NH:16][NH2:17])=[O:3])[CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22943407(3-Methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester

生成物 1

HCID 635792472-(3-Methyl-2-oxopyridin-1(2H)-yl)acetohydrazide収率 96%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

As described for example 112a, (3-methyl-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 72 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 96%). MS: m/e=204.4 [M+Na]+.

後処理

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

出典と根拠

ORDレコード
ord-3a53b2c8fed641548f22ade3e5cfc361
出典データセット
uspto-grants-2009_03
特許番号
US07507729B2

反応ノート

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