Hydrazine hydrate (1:1) → 2-Cyclopropyl-2-hydroxy-acetohydrazide
反応式
C[O:2][C:3](=O)[CH:4]([CH:6]1[CH2:8][CH2:7]1)[OH:5].O.[NH2:11][NH2:12]>CO>[CH:6]1([CH:4]([OH:5])[C:3]([NH:11][NH2:12])=[O:2])[CH2:8][CH2:7]1参加物
4
実験手順
As described for example 112a, (rac.)-2-cyclopropyl-2-hydroxy-acetic acid methyl ester (Newall, Christopher Earle; Foxton, Michael Walter; Hartley, Charles David; Looker, Brian Edgar. Cephalosporin antibiotics. Eur. Pat. Appl. (1985), 57 pp) in methanol was reacted with hydrazine hydrate (1.0 equivalent) at rt for 76 h. All volatiles were evaporated and the residue was triturated with hexane to afford the title compound as a white solid (yield: 69%). MS: m/e=112.2 [M−H2O]+.
後処理
- customAll volatiles were evaporated
- customthe residue was triturated with hexane
出典と根拠
- ORDレコード
- ord-108e5e87af074ab59bf196fe349f8eac
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07507729B2
反応ノート
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