Diisopropyl diazene-1,2-dicarboxylate → Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate

HRID 1786509ノート

反応式

HRID 1786509 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]2.[F:16][C:17]([F:27])([F:26])[CH2:18][N:19]1[CH2:24][CH2:23][CH:22](O)[CH2:21][CH2:20]1.N(C(OC(C)C)=O)=NC(OC(C)C)=O>>[F:27][C:17]([F:16])([F:26])[CH2:18][N:19]1[CH2:24][CH2:23][CH:22]([O:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]3)[CH2:21][CH2:20]1

参加物

4

反応物 3

HCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 90677Ethyl 5-hydroxy-1H-indole-2-carboxylateHCID 434262781-(2,2,2-Trifluoroethyl)piperidin-4-ol

生成物 1

HCID 68565990Ethyl 5-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yloxy]-1H-indole-2-carboxylate

実験手順

The title compound was prepared in analogy to example 40d), from ethyl 5-hydroxyindole-2-carboxylate and 1-(2,2,2-trifluoro-ethyl)piperidin-4-ol, using diisopropyl azodicarboxylate instead of diethyl azodicarboxylate. Off-white solid. MS (m/z): 371.2 (M+H)+.

出典と根拠

ORDレコード
ord-678c86ed5e184ea29bab85536d9aef8e
出典データセット
uspto-grants-2009_03
特許番号
US07507736B2

反応ノート

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