Sodium Hydroxide → HCID 178493213、化合物

HRID 1786727ノート

反応式

HRID 1786727 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 178493214Pantoprazole

生成物 1

HCID 178493213HCID 178493213、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 100 ml flask was charged with toluene (50.0 ml). Pantoprazole (5.0 g, 12.8 mmol) and 47% aqueous NaOH (1.2 g) were added to the stirred solvent at room temperature. The mixture was stirred until dissolution and then overnight until precipitation. The solid was filtered giving pantoprazole sodium. The sample was dried at 45° C. under 10 mm Hg vacuum overnight, giving 4.21 g of amorphous pantoprazole sodium.

後処理

  1. customovernight until precipitation
  2. filtrationThe solid was filtered

出典と根拠

ORDレコード
ord-accc83431eda449d8f9bf1d3f65d93f7
出典データセット
uspto-grants-2009_03
特許番号
US07507829B2

反応ノート

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