3-Hydroxybenzyl alcohol → 3-(Chloromethyl)phenol

3-Hydroxybenzylalcohol (5 g, 40 mmol) and triethylamine (5.2 ml, 60 mmol) were dissolved in benzene (250 ml), and thionylchloride (5.2 ml) dissolved in benzene (50 ml) was added thereto at 0° C. The brownish reacting solution was stirred at room temperature for 6 hours. When the reaction was completed, the solution was washed with brine, and the water layer was extracted with methylene chloride. The organic extract was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure to obtain the title compound (5.7 g, 99%).

1. additionwas added
2. customat 0° C
3. washthe solution was washed with brine
4. extractionthe water layer was extracted with methylene chloride
5. extractionThe organic extract
6. dry with materialwas dried over anhydrous magnesium sulfate
7. concentrationconcentrated under a reduced pressure

ORDレコード

ord-1d9b2f92f1e840efb716f8ecf6ea906d

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07741323B2