Trifluoroacetic acid → 4-Bromo-6-methoxyquinolin-3-amine

HRID 1787678ノート

反応式

HRID 1787678 の反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[Br:18])=[CH:15][C:14]([O:19][CH3:20])=[CH:13][CH:12]=2)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[Br:18])=[CH:15][C:14]([O:19][CH3:20])=[CH:13][CH:12]=2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68455075(4-Bromo-6-methoxy-quinolin-3-yl)-carbamic acid tert-butyl ester

生成物 1

HCID 684539074-Bromo-6-methoxyquinolin-3-amine収率 101.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(4-Bromo-6-methoxy-quinolin-3-yl)-carbamic acid tert-butyl ester (22.7 g, 0.0643 mole) was dissolved in CH2Cl2 (200 mL) and treated with trifluoroacetic acid (100 mL). After 3.5 hr at RT, the mixture was concentrated and the residue was dissolved in water. The solution was made basic with aqueous sodium carbonate. The precipitate was filtered off, washed with water, and dried at 40° C. in vacuo overnight, to give the title compound (16.46 g, 101%) as a white solid: MS (ES) m/e 254/256 (M+H)+.

後処理

  1. concentrationthe mixture was concentrated
  2. dissolutionthe residue was dissolved in water
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried at 40° C. in vacuo overnight

出典と根拠

ORDレコード
ord-bdf39d02b5a74856ba86c03a72223844
出典データセット
uspto-grants-2009_03
特許番号
US07511035B2

反応ノート

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