1-Amino-2-propanol → HCID 12384307、化合物

HRID 1787861ノート

反応式

HRID 1787861 の反応式
[NH2:1][CH2:2][CH:3]([OH:5])[CH3:4].[C:6]1(=O)[O:11][C:9](=[O:10])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12.C(N(CC)CC)C.C1(C)C=CC=CC=1>O>[CH2:6]([O:11][C:9]([NH:1][CH2:2][CH:3]([OH:5])[CH3:4])=[O:10])[C:7]1[CH:8]=[CH:12][CH:13]=[CH:14][CH:15]=1

参加物

6

反応物 4

HCID 41-Amino-2-propanolHCID 1140TolueneHCID 6811Phthalic AnhydrideHCID 8471Triethylamine

生成物 1

HCID 12384307HCID 12384307、化合物収率 142.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a round bottom flask equipped with Dean-Stark trap was added (1) (2 g, 7.4 mmol), phthalic anhydride (1.1 g, 7.4 mmol), triethylamine (0.1 mL) and toluene (50 mL). The reaction mixture was heated to reflux and water produced was collected. After refluxing for 2 hours, the solvent was removed. The residue was acidified using 1 N HCl, filtered and washed with water, dried to give 2.2 g of (2). 1H NMR (DMSO-d6, 400 MHz): δ 7.8 (m, 4H), 7.3 (m, 5H), 7.1 (d, 2H), 6.8 (d, 2H), 5.05 (m, 1H), 3.3 (m, 2H).

後処理

  1. customTo a round bottom flask equipped with Dean-Stark trap
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux
  4. customwas collected
  5. temperatureAfter refluxing for 2 hours
  6. customthe solvent was removed
  7. filtrationfiltered
  8. washwashed with water
  9. customdried

出典と根拠

ORDレコード
ord-2b99da6e97b8436a8959456d82cfddc4
出典データセット
uspto-grants-2009_03
特許番号
US07511063B2

反応ノート

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